The duo, who had won the Australian Open earlier this year, overcame several unforced errors in the first set to win the gruelling quarterfinal 3-6, 7-6 (4), 10-7.
Wawrinka's last ATP title came in 2017 before the former world number three underwent knee surgery.
Nadal believes he had no reason to feel alarmed ahead of the season's first Grand Slam starting in two weeks.
The German world number seven claimed his first ATP crown of the year after besting Canada's Felix Auger-Aliassime 6-3, 6-3 to win the bett1HULKS Indoor title at the same venue last Sunday.
Chile's Marcelo Rios suffered yet another home defeat in the final of the Bellsouth Open.\n\n
Carrying forward their good work at the Davis Cup, India's Somdev Devvarman and Rohan Bopanna have qualified for the BNP Paribas Open, an ATP Masters tournament in Indian Wells on Thursday.
Rohan Bopanna and his Romanian partner Florin Mergea on Saturday made it to the final of the men's doubles event at the ATP World Tour Finals, in London, after registering a straight-set victory against Croatian Ivan Dodig and Marcelo Melo of Brazil.
Take a look at the five top contenders for the men's singles title at the French Open:
Novak Djokovic has decided not to enter the Paris Masters because he has no points to win at the November 2-8 event as he bids to retain the world number one spot come end of season, the 33-year-old Serb said.
Canada's Milos Raonic boosted his chances of qualifying for the lucrative ATP World Tour Finals after capturing his first title of the season with a 6-3, 3-6, 6-3 win over Portugal's Joao Sousa in the final of the St. Petersburg Open on Sunday.
Croatia's Ivo Karlovic posted a 6-4, 6-1 victory over Argentine Mariano Zabaleta in the Houston final.
Rohan Bopanna and Eric Butorac claimed the doubles title in Los Angeles with a 7-6, 7-6 win over Travis Parrott and Dusan Vemic.
'If someone told me (I would end the year as number one) at that time it was looking quite improbable'
Carlos Alcaraz beat lucky loser Jan-Lennard Struff in the Madrid Open final on Sunday to defend last year's title and win his fourth ATP Tour trophy of the year
World number one Carlos Alcaraz retired injured against Holger Rune at the Paris Masters on Friday, sending his fellow 19-year-old through to the semi-finals, while Novak Djokovic and Felix Auger-Aliassime also sealed places in the last four.
Images from Day 8 of the 2022 Australian Open at Melbourne Park on Monday.
'They're incredible players, but they're not superheroes. The new generation has to start believing in themselves.'
Rohan Bopanna and his partner Aisam-ul-Haq Qureshi have advanced to the semi-finals of the ATP Tour event in Casablanca, Morocco after scoring an easy straight-set win over Simon Greul and Peter Luczak.
Rohan Bopanna and Aisam-ul Haq Qureshi advanced to the semi-finals of the ATP Tour event in Casablanca, Morocco, after a straight sets win over Simon Greul and Peter Luczak. The Indo-Pak pair beat the German-Australian pair 6-3, 6-2 in the quarter-finals of the euro 450,000 clay-court tournament.
IMAGES from the French Open quarter-finals played in Paris on Tuesday.
Novak Djokovic said he is still hoping for a final chapter in their storied rivalry.
Defending champion Stefanos Tsitsipas showed no signs of fatigue following Friday's marathon battle as he eased past German Alexander Zverev 6-4, 6-2 to reach the Monte Carlo Masters final on Saturday.
Novak Djokovic's outstanding serving, mighty forehand and all-court defence delivered him a ninth straight win over Stefanos Tsitsipas in their Red Group match.
Harsh Mankad and his partner Treat Conard Huey rallied from a set down to advance to the doubles semi-finals of the ATP Challenger event in Champaign, United States.
IMAGES from Day 10 of the Australian Open in Melbourne on Tuesday.
Indian Davis Cupper Rohan Bopanna and Frank Moser cruised into the doubles semi-finals of the Italy ATP Challenger event while Purav Raja and Sadi Kadir progressed to the quarter-finals of the Almaty Cup in Kazakhstan. The third seeded pair of Bopanna and Moser of Germany beat British duo of Jamie Delgado and Jamie Murray 6-3, 6-3 in the second round of the euro 64,000 clay-court event.
Spain's Rafael Nadal said on Wednesday that he is not sure if he will be able to play at next month's French Open.
Roger Federer trounced Croatian teenager Borna Coric 6-2, 6-1 at the Dubai Championships on Friday to set up a potential final showdown with world number one Novak Djokovic.
The 22-time major champion Rafael Nadal addressed the prospect that 2024 could be his final year as an ATP professional, confessing that it is indeed a reality that he might hang up his racquets at the end of next season.
The Paris Masters win catapulted Rohan Bopanna and Aisam-Ul-Haq Qureshi to fifth from seventh in the latest ATP Team Rankings, issued on Monday.
Italian top seed Matteo Berrettini marked himself down as a genuine Wimbledon threat after beating Britain's Cameron Norrie 6-4, 6-7(5), 6-3 to win the Queen's Club title on Sunday.
Three contenders for the men's singles title at the Australian Open, which starts on Sunday.
Somdev Devverman extended his brilliant run at the ATP Challenger event in Charlottesville in USA to book a berth in the semi-finals but it was curtains for compatriot Sanam Singh, who lost a hard-fought quarter-final.
Tsitsipas made short work of Norwegian eighth seed Casper Ruud as he seized a third Monte Carlo Masters title in four years with a 6-1, 6-4 victory on Sunday.
Rohan Bopanna and his partner Matwe Middelkoop beat Santiago Gonzalez and Andres Molteni in the summit clash to claim the doubles title at the ATP tennis tournament in Tel Aviv on Sunday.
Petra Kvitova overcame a sluggish start and 10 double faults to beat Madison Keys 6-7(6), 6-4, 6-3 on Saturday and advance to the final of the Cincinnati Open, where she will face Caroline Garcia, the first qualifier to reach the final of a WTA 1000 tournament.
Men's tennis steps into the unknown next week when the young guns expected to follow in the footsteps of the current golden generation contest the inaugural Next Gen ATP Finals in Milan.
Andy Murray crushed Stan Wawrinka 6-4, 6-2 to win his group at the ATP World Tour Finals on Friday and stay on course for a season-ending climax with Novak Djokovic.
Muguruza seals semi-final berth, Pliskova beats Krejcikova at WTA Finals.